The BRCA2 is a histone acetyltransferase

Circadian Regulator CLOCK Is a Histone Acetyltransferase

The molecular machinery that governs circadian rhythmicity comprises proteins whose interplay generates time-specific transcription of clock genes. The role of chromatin remodeling in a physiological setting such as the circadian clock is yet unclear. We show that the protein CLOCK, a central component of the circadian pacemaker, has histone acetyltransferase (HAT) activity. CLOCK shares homolo...

Querkopf, a histone acetyltransferase, is essential for embryonic neurogenesis.

DNA binding transcription factors require the presence of co-activators in order to exert their effects on the pattern of gene expression in a cell. An essential element of co-activator complexes is one or more proteins that have histone acetyltransferase activity. In a gene trap screen for mutations affecting brain development, we identified a member of the MYST family histone acetyltransferas...

The human histone acetyltransferase P/CAF is a promiscuous histone propionyltransferase.

Alcohol-Induced Neuroadaptation Is Orchestrated by the Histone Acetyltransferase CBP

Homeostatic neural adaptations to alcohol underlie the production of alcohol tolerance and the associated symptoms of withdrawal. These adaptations have been shown to persist for relatively long periods of time and are believed to be of central importance in promoting the addictive state. In Drosophila, a single exposure to alcohol results in long-lasting alcohol tolerance and symptoms of withd...

On the histone acetyltransferase hMOF

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